GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs8035452 | 1 | rs12900658 | chr15:51016364 | AP4E1 | chr15:51200946-51298097:+ | -0.1 | -3.86 | 0.00012 | Alzheimer's disease (late onset) |
| BRCA | cis | rs8035452 | 1 | rs12900658 | chr15:51016364 | SPPL2A | chr15:50999739-51057910:- | -0.11 | -4.07 | 4.95E-5 | Alzheimer's disease (late onset) |
| BRCA | cis | rs1322512 | 1 | rs1290296 | chr6:153010088 | SYNE1 | chr6:152442823-152958534:- | 0.09 | 3.56 | 0.000394 | Tonometry |
| BRCA | cis | rs1322512 | 1 | rs1290296 | chr6:153010088 | VIP | chr6:153071933-153080898:+ | -0.13 | -4.22 | 2.68E-5 | Tonometry |
| BRCA | cis | rs3784262 | 1 | rs12903474 | chr15:58276747 | ALDH1A2 | chr15:58245628-58571462:- | -0.09 | -3.4 | 0.000708 | Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) |
| BRCA | cis | rs7178375 | 1 | rs12907055 | chr15:31204294 | MTMR15 | chr15:31196055-31235307:+ | 0.15 | 3.58 | 0.000353 | Hypertriglyceridemia |
| BRCA | cis | rs903552 | 1 | rs12908406 | chr15:102004046 | ASB7 | chr15:101142755-101191902:+ | -0.14 | -3.57 | 0.000367 | Diabetic kidney disease |
| BRCA | cis | rs748404 | 1 | rs12909095 | chr15:43558142 | STRC | chr15:43891762-43924561:- | 0.17 | 4.27 | 2.11E-5 | Lung cancer |
| BRCA | cis | rs3743162 | 1 | rs12909280 | chr15:85429356 | LOC388152 | chr15:84867600-84898920:- | -0.17 | -4.33 | 1.6E-5 | Alzheimer's disease (age of onset) |
| BRCA | cis | rs3743162 | 1 | rs12909280 | chr15:85429356 | SLC28A1 | chr15:85427913-85518876:+ | -0.17 | -4.19 | 2.96E-5 | Alzheimer's disease (age of onset) |
| BRCA | cis | rs748404 | 1 | rs12911132 | chr15:43560436 | STRC | chr15:43891762-43924561:- | 0.17 | 4.14 | 3.77E-5 | Lung cancer |
| BRCA | cis | rs997295 | 1 | rs12914773 | chr15:68019958 | IQCH | chr15:67547188-67794139:+ | 0.14 | 5.08 | 4.54E-7 | Motion sickness |
| BRCA | cis | rs997295 | 1 | rs12914773 | chr15:68019958 | LBXCOR1 | chr15:68117941-68126174:+ | 0.12 | 3.73 | 0.000201 | Motion sickness |
| BRCA | cis | rs3743162 | 1 | rs12917429 | chr15:85425097 | LOC388152 | chr15:84867600-84898920:- | 0.16 | 3.94 | 8.6E-5 | Alzheimer's disease (age of onset) |
| BRCA | cis | rs3743162 | 1 | rs12917429 | chr15:85425097 | SLC28A1 | chr15:85427913-85518876:+ | 0.17 | 4.01 | 6.47E-5 | Alzheimer's disease (age of onset) |